Table 2.

Results of multivariable MR analysis.

MVMR Method	Exposure	Outcome	OR	95% CI	p
IVW	BMI	IVDD	1.189	1.097–1.288	<0.001
	T2DM		1.080	1.041–1.121	<0.001
MR-Egger	BMI	IVDD	1.183	0.980–1.428	0.08
	T2DM		1.080	1.041–1.121	<0.001
MR-Lasso	BMI	IVDD	1.190	1.105–1.282	<0.001
	T2DM		1.078	1.039–1.115	<0.001

MVMR, multivariable Mendelian randomization; IVDD, intervertebral disc degeneration; T2DM, Type 2 diabetes mellitus; BMI, body mass index; IVW, inverse-variance weighted; OR, odd ratio; CI, confidence interval.