Table 1.
Studies |
Effect Estimates | Mean Differences in TG levels (mmol/L) (smokers – non-smokers) |
|||
---|---|---|---|---|---|
Region | Fixed Effects [95% CI] | I2 (%) | Random Effects [95% CI] | ||
US & Canada | 23 | 34 | 0.08 [0.07, 0.10] | 82 | 0.18 [0.12, 0.23] |
Europe | 51 | 73 | 0.24 [0.24, 0.25] | 96 | 0.21 [0.17, 0.26] |
Asia | 43 | 72 | 0.46 [0.46, 0.47] | 100 | 0.29 [0.20, 0.38] |
Latin America | 5 | 5 | 0.15 [0.00, 0.30] | 36 | 0.17 [− 0.03, 0.36] |
Middle East | 18 | 21 | 0.11 [0.09, 0.13] | 97 | 0.35 [0.23, 0.46] |
Indian Subcontinent | 23 | 26 | 0.76 [0.74, 0.79] | 98 | 0.49 [0.30, 0.68] |
Australia | 2 | 4 | 0.16 [0.03, 0.30] | 11 | 0.18 [0.02, 0.34] |
Africa | 4 | 4 | 0.13 [0.08, 0.17] | 87 | 0.13 [0.00, 0.26] |
Study Design | |||||
Cross Sectional | 143 | 202 | 0.13 [0.12, 0.13] | 98 | 0.26 [0.23, 0.30] |
Cohort | 19 | 29 | 0.58 [0.58, 0.58] | 99 | 0.27 [0.19, 0.35] |
Case Control | 5 | 6 | 0.29 [0.25, 0.32] | 97 | 0.40 [0.17, 0.64] |
RCT | 2 | 2 | NA | NA | NA |
Period of Publication | |||||
1970 s | 4 | 5 | 0.43 [0.38, 0.47] | 95 | 0.30 [0.03, 0.56] |
1980 s | 24 | 40 | 0.25 [0.22, 0.28] | 53 | 0.24 [0.19, 0.30] |
1990 s | 37 | 54 | 0.17 [0.16, 0.18] | 82 | 0.22 [0.18, 0.26] |
2000 s | 51 | 72 | 0.25 [0.24, 0.26] | 99 | 0.23 [0.15, 0.32] |
2010 s | 43 | 58 | 0.08 [0.08, 0.09] | 98 | 0.33 [0.28, 0.38] |
2020 s | 10 | 10 | 0.59 [0.58, 0.59] | 100 | 0.35 [0.24, 0.47] |
Smoking Definitiona | |||||
None/Other | 128 | 163 | 0.16 [0.16, 0.17] | 98 | 0.25 [0.21, 0.28] |
> 10 CPD | 11 | 12 | 0.37 [0.31, 0.43] | 65 | 0.34 [0.22, 0.46] |
> 15 CPD | 9 | 11 | 0.41 [0.35, 0.48] | 97 | 0.24 [− 0.19, 0.66] |
> 20 CPD | 40 | 53 | 0.60 [0.60, 0.61] | 93 | 0.33 [0.26, 0.40] |
Sexa | |||||
Males | 82 | 105 | 0.30 [0.29, 0.30] | 98 | 0.31 [0.24, 0.37] |
Females | 35 | 48 | 0.05 [0.05, 0.06] | 86 | 0.16 [0.12, 0.19] |
Combined | 70 | 86 | 0.52 [0.52, 0.52] | 99 | 0.29 [0.22, 0.35] |
Total | 169 | 239 | 0.41 [0.41, 0.42] | 99 | 0.27 [0.23, 0.32] |
The sum of studies does not add to 169, as some studies provided multiple stratum-specific estimates.