Table 2B.

Group 2: tumor >3 cm, but <=4 cm.

Variables	Univariate analysis		Multivariable analysis$
	HR (95% CI)	P value	aHR* (95% CI)	P value
Overall survival:
Age 65-74	1.45 (1.07-1.98)	0.018	1.46 (1.06-2.01)	0.019
Male	1.34 (0.98-1.83)	0.062
High grade	1.67 (1.19-2.31)	0.003	1.62 (1.14-2.28)	0.006
VPI present	1.01 (0.74-1.38)	0.947
Sublobar resection	1.91 (1.10-3.11)	0.014
N2 dissection, LN station <3	1.11 (0.76-1.59)	0.573
Ever smoker	1.68 (1.22-2.30)	0.001	1.55 (1.01-2.41)	0.049
ECOG PS 1	1.33 (0.95-1.83)	0.088
Regional hospital	1.23 (0.86-1.73)	0.242
Adjuvant chemotherapy	0.49 (0.36-0.67)	<0.001	0.52 (0.38-0.72)	<0.001
>=1 Risk factors*	1.84 (1.34-2.52)	<0.001	1.73 (1.25-2.39)	<0.001
Cancer-specific survival:
Age 65-74	1.38 (0.96-1.97)	0.079
Male	1.32 (0.92-1.89)	0.131
High grade	1.68 (1.13-2.45)	0.009	1.64 (1.09-2.44)	0.016
VPI present	0.93 (0.64-1.34)	0.715
Sublobar resection	2.31 (1.26-3.89)	0.003	1.82 (0.98-3.15)	0.043
N2 dissection, LN station <3	1.26 (0.82-1.88)	0.279
Ever smoker	1.70 (1.17-2.45)	0.004
ECOG PS 1	1.33 (0.90-1.93)	0.142
Regional hospital	1.24 (0.81-1.83)	0.303
Adjuvant chemotherapy	0.50 (0.35-0.71)	<0.001	0.54 (0.37-0.78)	0.001
>=1 Risk factors*	1.95 (1.34-2.80)	<0.001	1.84 (1.26-2.67)	0.001

HR, hazard ratio; aHR, adjusted hazard ratio; CI, confidence interval; PS, performance status; VPI, visceral pleural invasion. ^* The risk factor refers to having either high-grade histologic findings or receiving sublobar resection. ^$In multivariable analysis, only factors reaching statistical significance were listed on the table. ^*Hazard ratio was adjusted by age, sex, histologic grade, visceral pleural invasion (VPI), extent of resection, smoking status, performance status, and the types of health care institutions.