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. 2023 Feb 21;34(3):ar18. doi: 10.1091/mbc.E22-10-0473

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© 2023 Palicharla et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 3: — TULP3 is required for trafficking of ARL13B- and ARL13B-dependent lipidated cargoes to mouse kidney epithelial cilia. (A–D) Kidney sagittal sections at postnatal day 0, 5, or 24 were immunostained for ARL13B (A), INPP5E (B), NPHP3 (C), or LKB1 (D), acetylated tubulin (AcTUB) and Aquaporin 2 (AQP2) and counterstained for DNA. (E, F) Quantification from two to four mice/genotype. Cilia counted by AcTUB staining. n > 200 cilia/mouse and genotype. Data represent mean ± SD. CD, collecting ducts. Scale, 5 μm. ****, p < 0.0001; **, p < 0.01; *, p < 0.05; ns, not significant, all compared with respective P0 values. ^#, p < 0.0001 with respect to ARL13B+ cilia in control animals at P0. Arrows and arrowheads indicate cilia positive and negative for the indicated proteins, respectively.