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. 2023 Feb 9;299(3):102995. doi: 10.1016/j.jbc.2023.102995

Figure 6.

Figure 6

Molecular mechanisms of how APP, FUS, and TDP-43 effects on poly(GR) expression. A model illustrating the mechanism by which APP, FUS, or TDP-43 suppresses poly(GR) expression. One the one hand, APP/TDP43/FUS act as upstream regulators of the mTORC2/AKT/VCP axis to regulate the RQC of poly(GR). On the other hand, APP/TDP43/FUS represses the overall translation of stalled poly(GR) mRNA and possibly other stalled mRNAs. APP, amyloid precursor protein; FUS, fused in sarcoma; mTORC2, mechanistic target of rapamycin complex 2; RQC, ribosome-associated quality control; TDP-43, TAR DNA-binding protein 43; VCP, valosin-containing protein.