Table 2.
Predictors of late hepatocellular carcinoma recurrence after curative treatment
|
Predictors related to HCC characteristics
|
Ref.
|
Predictors related to patient characteristics
|
Ref.
|
Predictors related to treatment
|
Ref.
|
| Size > 5 cm | [92] | Liver cirrhosis | [32,41,43,84,93-96] | RFA (vs LR) | [41,88,117-119] |
| Multifocality | [92,93] | Old age | [41,92] | ||
| Microvascular invasion | [92] | Male sex | [93] | ||
| AFP > 400 μg/L | [94] | LSM | [43,102] | ||
| Portal hypertension | |||||
| SSM (> 70 kPa) | [43] | ||||
| Splenic volume (> 165 mL) | [40] | ||||
| Platelet count | [43,103,104] | ||||
| Esophageal varices | [43,103] | ||||
| HBV infection | |||||
| High viral load | [105,108] | ||||
| Low viral load | [111] | ||||
| High HBsAg levels | [84,86,103,107] |
AFP: Alpha-fetoprotein; HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; LR: Liver resection; LSM: Liver stiffness; RFA: Radio-frequency ablation; SSM: Splenic stiffness.