. 2023 Mar 13;80(5):455–461. doi: 10.1001/jamaneurol.2023.0183

Table 4. Risk of Incident Parkinson Disease According to Frailty Status Within Polygenic Risk Category, UK Biobank 2006 to 2010^a.

Frailty status	PRS (HR [95% CI])			P value for interaction^a
Frailty status	Low	Intermediate	High	P value for interaction^a
Frailty	1 [Reference]	1 [Reference]	1 [Reference]	.008
Prefrailty	0.78 (0.54-1.12)	0.65 (0.46-0.91)	0.64 (0.47-0.87)
Nonfrailty	0.57 (0.39-0.84)	0.45 (0.32-0.65)	0.58 (0.42-0.79)

^{^a}

Model adjusted for age, sex, Townsend deprivation index, assessment centers, alcohol consumption, smoking status, body mass index, the number of long-term morbidities, genotyping array, and the first 10 principal components of ancestry.

^{^b}

P value for the interaction between frailty status and polygenic risk score categories.

Table 4. Risk of Incident Parkinson Disease According to Frailty Status Within Polygenic Risk Category, UK Biobank 2006 to 2010a.

Table 4. Risk of Incident Parkinson Disease According to Frailty Status Within Polygenic Risk Category, UK Biobank 2006 to 2010^a.