Table 2.
Associations between maternal and placental characteristics and fetal liver measurements.
| Fetal liver | r2 | P value | FDR | |
|---|---|---|---|---|
| Dam metabolism | ||||
| Body wt | miR-1285-3p | +0.43 | 0.0171 | 0.1467 |
| VEGFA | +0.43 | 0.0322 | 0.1816 | |
| NFE2L2 | -0.46 | 0.0136 | 0.1405 | |
| SSF | CYP1A1 | -0.57 | 0.0074 | 0.1368 |
| Dam lipid metabolism | ||||
| TGs | TGs | +0.60 | 0.0088 | 0.1368 |
| ICAM1 | -0.47 | 0.0254 | 0.1577 | |
| NFE2L2 | -0.39 | 0.0321 | 0.1816 | |
| ACACA | -0.4 | 0.0403 | 0.1924 | |
| HDL | TGs | +0.45 | 0.0207 | 0.1565 |
| miR-145-3p | -0.62 | 0.0042 | 0.1368 | |
| LDL/VLDL | TGs | +0.87 | 0.0001 | 0.0197 |
| miR204-5p | -0.47 | 0.0177 | 0.1467 | |
| miR204-5p:sex | M: -0.69; F: -0.12 | 0.0464 | 0.2054 | |
| Placenta | ||||
| Weight | miR-34a-5p | +0.64 | 0.0061 | 0.1368 |
| TREM2 | +0.53 | 0.0245 | 0.1577 | |
| TLR4 | +0.53 | 0.0254 | 0.1577 | |
Maternal measures were compared to fetal liver miRNA and mRNA expression using ANOVA with LASSO regularization for variable selection.
HDL, high-density lipoprotein; LDL, low-density lipoprotein; SSF, sum of skin folds; TG, triglyceride; VLDL, very low-density lipoprotein; wt, weight.