Table 4.

Associations between miRNAs and fetal liver mRNA expression levels.

Pathway/mRNA	Fetal liver miRNA	Placental miRNA	r2	P value	FDR
Lipid metabolism/synthesis
ACACA	–	miR-183-5p	+0.59	0.0096	0.0564
ACACA	–	miR-182-5p	+0.44	0.0305	0.0983
FASN	–	miR-185-5p	+0.39	0.0414	0.1132
FASN	–	miR-145-3p	-0.54	0.0151	0.0624
HMOX1	–	miR-183-5p	+0.70	0.0036	0.0520
SREBP1	–	miR-185-5p	+0.40	0.0394	0.1132
Oxidative stress
NFE2L2	miR-1285-3p	–	-0.50	0.0091	0.0564
NFE2L2	-	miR-1285-3p	+0.48	0.0107	0.0564
Inflammation
ICAM1	miR-1285-3p	–	-0.63	0.0063	0.0564
IL10	–	miR-183-5p	+0.45	0.0288	0.0983
IL10	miR-29a-3p	–	-0.58	0.0104	0.0564
IL10	miR-34a-5p	–	-0.39	0.0420	0.1132
IL6	miR-1285-3p	–	+0.76	0.0006	0.0334
NCF4	–	miR-182-5p	+0.48	0.0228	0.0827
VCAM1	miR-1285-3p	–	-0.63	0.0063	0.0564
VEGFA	–	miR-185-5p	+0.59	0.0093	0.0564
VEGFA	–	miR-29a-3p	-0.37	0.0483	0.1167
Stellate cells activation and fibrosis
COL1A1	miR-204-5p	–	+0.61	0.0132	0.0624
TGFB1	–	miR-183-5p	+0.69	0.0036	0.0520
TGFB1	–	miR-182-5p	+0.54	0.0149	0.0624
FAP	–	miR-1285-3p	-0.49	0.0211	0.0814
TNFSF12	mir-183-5p	–	+0.38	0.0461	0.1163

Fetal liver mRNA expression was compared to placental and liver miRNA expression using ANOVA models with LASSO regularization for variable selection.