Fig. 8. Compartment modeling to understand depot pharmacokinetics in humans. (a) Two compartment model schema with first-order kinetics between compartments, including relevant physiological parameters and antibody drug characteristics. Pharmacokinetic profiles were generated for antibodies with different elimination half-lives to simulate antibody release from subcutaneous depots exhibiting different release rate constants: (b) IgM class antibodies, (c) VRC01, an anti-HIV bnAb, (d) REGN-COV2, antibody cocktail against SARS-CoV-2, and (e) mAb-LS, indicating a bnAb modified with the LS mutation to increase serum half-life. Arrows on bars indicate that serum titer remained above the 3 μg mL−1 threshold beyond 365 days.
