Table 9.
Analysis of key metabolic pathways in rat liver tissue metabolism
| No. | Pathway Name | Total | Hits | Raw p | Holm adjust | FDR p | Impact |
|---|---|---|---|---|---|---|---|
| 1 | Biosynthesis of unsaturated fatty acids | 36 | 6 | 0.000099 | 0.008348 | 0.008348 | 0 |
| 2 | Glycerophospholipid metabolism | 36 | 4 | 0.0076 | 0.63076 | 0.31918 | 0.29983 |
| 3 | alpha-Linolenic acid metabolism | 13 | 2 | 0.032911 | 1 | 0.92151 | 0.33333 |
| 4 | Arachidonic acid metabolism | 36 | 3 | 0.044951 | 1 | 0.94396 | 0.0212 |
| 5 | Pantothenate and CoA biosynthesis | 19 | 2 | 0.06634 | 1 | 1 | 0.27857 |
| 6 | Sphingolipid metabolism | 21 | 2 | 0.079235 | 1 | 1 | 0.15822 |
| 7 | Linoleic acid metabolism | 5 | 1 | 0.10783 | 1 | 1 | 0 |
| 8 | Taurine and hypotaurine metabolism | 8 | 1 | 0.16702 | 1 | 1 | 0 |
| 9 | Ascorbate and aldarate metabolism | 10 | 1 | 0.20434 | 1 | 1 | 0 |
| 10 | Butanoate metabolism | 15 | 1 | 0.29068 | 1 | 1 | 0 |
| 11 | Glycerolipid metabolism | 16 | 1 | 0.30683 | 1 | 1 | 0.01246 |
| 12 | Ether lipid metabolism | 20 | 1 | 0.3679 | 1 | 1 | 0 |
| 13 | Citrate cycle (TCA cycle) | 20 | 1 | 0.3679 | 1 | 1 | 0.03273 |
| 14 | Propanoate metabolism | 23 | 1 | 0.41025 | 1 | 1 | 0 |
| 15 | Alanine, aspartate and glutamate metabolism | 28 | 1 | 0.47478 | 1 | 1 | 0 |
| 16 | Phosphatidylinositol signaling system | 28 | 1 | 0.47478 | 1 | 1 | 0.00152 |
| 17 | Glutathione metabolism | 28 | 1 | 0.47478 | 1 | 1 | 0.02698 |
| 18 | Arginine and proline metabolism | 38 | 1 | 0.58393 | 1 | 1 | 0.01212 |
| 19 | Tyrosine metabolism | 42 | 1 | 0.62112 | 1 | 1 | 0.05581 |
| 20 | Primary bile acid biosynthesis | 46 | 1 | 0.65508 | 1 | 1 | 0.02285 |
| 21 | Purine metabolism | 66 | 1 | 0.78516 | 1 | 1 | 0 |
Notes: total: total number of compounds in the pathway; hits: actually matched number from the user uploaded data; raw p: original P value calculated from the enrichment analysis; holm p: P value adjusted by holm-bonferroni method; FDR p: P value adjusted using false discovery rate; impact: pathway impact value calculated from pathway topology analysis. FDR: false discovery rate.