Table 2. Microfluidic EV Isolation Methods.

isolation method	advantages	disadvantages
filtration	minute volume of samples (μL, nL, pL, fL), adjustable microchannel size (nm to μm), simple assembly and operation	complicated and time-consuming fabrication process, clogging
inertial lift force	rapid processing with controlled pressure and speed	co-isolation of small particles
viscoelastic flow	high yield with easy automation and integration	addition of reagents
acoustic waves	high purity and efficiency	requires external force, potential damage to exosomes