Figure 2.

(A) Activity of 17 in a parasite reduction ratio assay in comparison to antimalarial drugs. Data represent the means and SDs of three replicate experiments using Pf 3D7 parasites in a ³H-hypoxanthine assay. (B) Representative Giemsa-stained microscopy images showing the asexual stage of arrest treated with ATQ (3), 17, and 41. Other representative images can be found in Figure S2. (C) Flow cytometry of SYBR green-stained infected RBCs. Data points represent the mean of three technical replicates analyzed via flow cytometry. Compounds in these experiments were used at a concentration 10 times the asexual EC₅₀ value.