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Reagents and conditions: (a) EtI, DMF, 70 °C, 24 h; (b) amine, DMSO, 120 °C, 3 h; (c) Pd(OAc)2, BINAP, Cs2CO3, DMF, 115 °C, 2 h; (d) LiOH, THF/H2O (1:1), rt, 2 h; (e) Et3N, methyl chloroformate, DCM, rt; and (f) N′-hydroxyacetamidine, NaOH, DMSO, 60 °C.
