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. 2023 Feb 28;9(3):668–691. doi: 10.1021/acsinfecdis.2c00607

Table 2. Evaluation of Aqueous Solubility, In Vitro Metabolism, and LogD for Selected Compounds.

  aqueous solubility
 liver microsomes
 hepatocytes  
cmpd pH 7.4 (μM)a pH 6.5 (μM)b pH 1.2 (μM)c mouse CLint (μL/min/mg) human CLint (μL/min/mg) rat CLint (μL/min/106 cells) logDd
17 <1.2 1.5 4.6 16.2 12.4 53.8 2.6
21 22.9       205.2 >92.4 3.2
41 <1.2     44.1 101.9 24.7 4.2
43 10.4       193.2 >92.4 4.6
a

Kinetic in PBS.

b

Kinetic FaSSIF.

c

Kinetic FaSSGF.

d

Shake-flask method.