. 2023 Feb 28;9(3):668–691. doi: 10.1021/acsinfecdis.2c00607

Table 5. Evaluation of Selected Compounds against Drug P. falciparum Strains.

		Pf multidrug-resistant strain EC₅₀ μM^a
cmpd	Dd2 EC₅₀ μM^a	Dd2 ^{CARL (I1139K)}	Dd2 ^{DHODH (C276F)}	Dd2 ^eEF2 (Y86N)	Dd2 ^{PI4K (S743T)}	K1	NF54	RF12	7G8
17	0.010	0.009	0.015	0.008	0.011	0.009	0.012	0.006	0.009
21	0.055	0.020		0.018	0.027	0.048	0.065	0.020	0.038
41	0.004	0.004	0.005	0.003	0.005	0.005	0.005	0.002	0.003
43	0.015	0.007		0.006	0.009	0.014	0.017	0.005	0.012
KAF156	0.008	1.53
DSM265	0.024		0.47
DDD107498	0.0004			0.85
MMV048	0.016				0.12

EC₅₀ data represent means for two ³H-hypoxanthine experiments using a selection of drug-resistant P. falciparum strains following exposure to compounds in 10-point dilution series for 72 h. Data for each experiment are shown in Table S4.