Table 6. P. falciparum Liver Stage and Gamete Activity of Selected Compounds.
| liver stage |
transmission stage |
|||
|---|---|---|---|---|
| cmpd | Pb liver stage EEFs EC50 (SD) μMa | HepG2 EC50 μMb | male gamete EC50 μMc | female gamete EC50 μMc |
| 17 | <0.001 | >50 | 0.56 | >25 |
| 21 | 0.024 (0.003) | >50 | 0.15 | >25 |
a
EC50 data represent means and SDs for four technical replicates following exposure to compounds in 10-point dilution series over 48 h.
b
Activity was determined using a 48 h CellTiter-Glo assay.
c
Data represent means from four replicate experiments using NF54 parasites in a DGFA. Dose–response curves with error values are shown in Figure S6.