Table 7. Evaluation of 17 in a Peter’s 4 Day P. berghei Mouse Model^a.

compound	17	CQ	vehicle
dose (mg/kg)	20	10
% parasitemiab	8.1	0.02	18.5
% reduction in parasitemiac	56.2	99.8

^aP. berghei ANKA parasites expressing GFP were injected into the tail vein to infect mice on day 0. Compound 17 was administered q.d. at 20 mg/kg by p.o. 2 h after infection (day 0) and then on days 1, 2, and 3. Parasitemia was measured by flow cytometry. Figure S7 shows data for individual mice. CQ = chloroquine.

^bAverage % parasitemia for four mice on day 4.

^cAverage % reduction in parasitemia versus the vehicle control for four mice on day 4.