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. 2023 Mar 14;13:4216. doi: 10.1038/s41598-023-31118-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Metaproteomic analysis result. (a) Heatmap of abundance of fecal proteins derived from the top 10 bacterial families for ten individuals both before (Ss+PreT (T1)) and after ivermectin treatment (Ss+PostT (T2)). (b) Relative levels of the beta-N-acetylglucosaminidase enzyme of Ruminococcus torques expressed in Ss+PreT and Ss+PostT groups by log2 max intensity peptide count. Data are presented as line graphs pre- and post-treatment of individual samples (7/10 samples contained this protein) and as a bar chart. Each column shows data from a single individual. (c) Jvenn diagram showing numbers of highly expressed proteins (HEPs) in Ss+PreT and Ss+PostT groups and (d) functional categories of HEPs in Ss+PreT in a pie chart.