Patient or population: adults infected with mpox Setting: UK Intervention: bricidofoviraa
Outcomes	Number of events with brincidofovir n (%)	No. of participants (studies)	Comment
Serious adverse events	3 (100%)	3 (1)	Three out of three participants treated with brincidofovir across one study reported elevated alanine transaminase levels.
Mental health outcomes	2 (67%)	3 (1)	Two out of three participants treated with brincidofovir across one study reported mental health outcomes, including low mood and emotional lability.
Footnotes aThe included studies do not include control populations; therefore, there are no comparison statistics included in the results table and no GRADE assessment has been performed. We judged these studies to be at critical risk of bias due to an observational, non‐comparative study design.