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. Author manuscript; available in PMC: 2023 Dec 21.
Published in final edited form as: Cell Syst. 2022 Dec 2;13(12):1048–1064.e7. doi: 10.1016/j.cels.2022.11.003
Parameter Name Parameter Value Annotation
Ksxs 0.02 Basal production rate of HIF-1α
Ksx 1 Max HIF-1α production rate affected by HIF-1α
Kpx 1 The constant defining the HIF-1α positive feedback
Kdx 0.2 Basal HIF-1α degradation rate
Kdxs 1 HIF-1α degradation rate affected by lactate
ksy 0.01 Lactate production rate
kpy 1 The regulating for lactate production
kdy 0.01 Basal lactate degradation rate
HIF[0] 0.1 The initial HIF-1α concentration
Lactate[0] 0.2 The initial lactate concentration
GFP[0] 0 The initial GFP concentration
Vg 1 The GFP production rate
kg 0.05 The constant defining GFP production
dg 0.1 GFP degradation rate