Fig. 1.

Comparisons and correlation analysis of CSF sPDGFRβ levels as well as Q-alb levels in groups with different cognitive stages. Analysis of covariance (ANCOVA) was used to perform multiple comparisons of ln-transformed s Q-alb ratios (A) and ln-transformed CSF sPDGFRβ concentrations (B) between CDR 0 group, CDR 0.5 A−, CDR 0.5 A+ group, and CDR 1–2 group. Sex, age, and APOE genotype were adjusted as covariates. The middle line of the boxplot represents the median value of the group, and the lower and upper lines represent the first and third quantiles, respectively. Multiple linear regression models were used to analyze the correlation between ln-transformed Q-alb ratios and CSF sPDGFRβ levels in the whole cohort (C) and in different cognitive groups (D). Sex, age, and APOE genotype were adjusted as covariates. Standardized regression coefficients and p values are presented. A value of p < 0.05 was considered statistically significant after false discovery rate post hoc analysis for multiple comparisons