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. 2023 Mar 14;15:51. doi: 10.1186/s13195-023-01199-5

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Mediation analysis regarding the proportion to which CSF sPDGFRβ alteration affects the process of BBB damage. Mediation analysis included the following variables: the concentration of CSF sPDGFRβ was treated as a mediator, Q-alb was set as the dependent variable, and Aβ42/Aβ40 ratio was set as the independent variable. Analyses based on multiple linear regression models with sex, age, and APOE genotype was adjusted as covariates. The values for CSF sPDGFRβ levels and the Q-alb ratio were ln-transformed. A value of p < 0.05 was considered statistically significant