Table 1.

Demographic characteristics of subjects

		CDR = 0	CDR = 0.5	CDR 1~2
No.		27	48	83
Male, %		15/27 (55.56%)c	19/48 (39.58%)	26/83 (31.33%)a
Age, years	Mean ± SD	60.70 ± 6.64c	63.19 ± 8.96	64.69 ± 7.57a
	Median	61.00	64.00	67.00
	95% CI	58.08, 63.33	60.59, 65.79	63.03, 66.34
Education, years	Mean ± SD	8.30 ± 3.91	9.29 ± 4.78c	6.93 ± 4.70b
	Median	9.00	10.00	8.00
	95% CI	6.75, 9.84	7.90, 10.68	5.90, 7.95
MMSE, scores	Mean ± SD	27.51 ± 2.34b, c	22.60 ± 4.16a, c	12.18 ± 5.86a, b
	Median	28.00	23.50	13.00
	95% CI	26.59, 28.45	21.40, 23.81	11.35, 13.91
APOE e4 carriers, n (%)		4 (14.81%)b, c	22 (45.83%)a, c	53 (63.86%)a, b
Amyloid positive, %		3 (11.11%)	28 (58.33%)	83 (100.00%)
Q-alb (× 103)	Mean ± SD	7.10 ± 2.97c	8.57 ± 3.47	9.40 ± 4.06a
	Median	6.51	8.10	8.63
	95% CI	5.93, 8.28	7.52, 9.61	8.48, 10.32
CSF sPDGFRβ	Mean ± SD	179.83 ± 51.23b	252.50 ± 57.11a, c	219.15 ± 61.05b
	Median	166.66	249.79	220.57
	95% CI	0.06, 0.07	235.34, 269.65	205.65, 232.65
CSF p-tau, pg/ml	Mean ± SD	33.84 ± 8.81b, c	76.67 ± 55.72a, c	130.87 ± 86.29a, b
	Median	34.90	56.00	110.00
	95% CI	30.12, 37.55	60.31, 93.03	112.03, 149.71
CSF t-tau, pg/ml	Mean ± SD	74.44 ± 21.91b, c	124.73 ± 66.56a, c	198.13 ± 137.29a, b
	Median	75.53	108.00	164.80
	95% CI	65.59, 83.29	105.18, 144.27	168.16, 228.11
CSF Aβ42, pg/ml	Mean ± SD	700.61 ± 338.99b, c	463.52 ± 286.36a, c	290.24 ± 153.02a, b
	Median	669.60	368.95	273.20
	95% CI	560.68, 840.54	379.44, 547.60	256.61, 323.86
CSF Aβ40, pg/ml	Mean ± SD	7428.22 ± 3220.53	6972.30 ± 2511.04	6288.86 ± 2897.36
	Median	8000	6712	6112
	95% CI	6098.86, 8757.59	6226.62, 7717.99	5639.89, 6937.84
CSF Aβ42/Aβ40 ratio	Mean ± SD	0.094 ± 0.02b, c	0.064 ± 0.03a, c	0.046 ± 0.01a, b
	Median	0.10	0.06	0.04
	95% CI	0.09, 0.10	0.06, 0.07	0.04, 0.05

p-tau phosphorylated tau, t-tau total tau

p < 0.05 was considered statistically significant

^aSignificant values vs CDR 0

^bSignificant values vs CDR 0.5

^cSignificant values vs CDR 1–2