Table 1.
Characteristics of bleeding among treatment groups
| TachoSil® | Veriset™ | ORC-PLGA-NHS-POx: NU-POx | GFC-NHS-POx | GFC Blank | GFC-NHS-POx 1.5 | |
|---|---|---|---|---|---|---|
| Experiment 1 | ||||||
| Liver biopsy (n) | 40 | 40 | 40 | 40 | 40 | N/A |
| Blood flow (ml/min)* | 8.2 (3.5) | 8.2 (3.2) | 7.4 (2.0) | 7.9 (2.4) | 7.8 (2.5) | N/A |
| Mean arterial pressure (mm Hg) | 55.5 (11.7) | 54.0 (11.7) | 52.6 (7.6) | 54.3 (11.8) | 53.9 (12.3) | N/A |
| Spleen biopsy (n) | 20 | 20 | 20 | 20 | 20 | N/A |
| Blood flow (ml/min)* | 7.7 (1.7) | 6.9 (1.6) | 6.8 (1.1) | 7.4 (1.8) | 6.9 (1.0) | N/A |
| Mean arterial pressure (mm Hg) | 53.8 (11.9) | 53.4 (12.0) | 52.8 (10.3) | 51.2 (6.9) | 54.8 (11.6) | N/A |
| Experiment 2 Non-heparinized pigs | ||||||
| Liver resections (n) | 7 | 8 | 6 | 7 | N/A | 8 |
| Spleen resections (n) | 8 | 6 | 8 | 7 | N/A | 7 |
| Mean arterial pressure (mm Hg) | 49.0 (3.0) | 46.7 (7.1) | 47.4 (5.7) | 37.2 (11.5) | N/A | 46.1 (6.4) |
| ACT baseline (s) | 98 | 90 | 98 | 86 | N/A | 102 |
| ACT during experiment (s) | 98 | 90 | 89 | 87 | N/A | 98 |
| Experiment 2 Heparinized pigs | ||||||
| Liver resections (n) | 5 | 6 | 5 | 5 | N/A | 7 |
| Spleen resections (n) | 8 | 4 | 8 | 6 | N/A | 6 |
| Mean arterial pressure (mm Hg) | 49.9 (13.4) | 42.4 (6.1) | 56.7 (6.5) | 46.0 (9.0) | N/A | 50.4 (7.5) |
| ACT baseline (s) | 92 | 87 | 92 | 98 | N/A | 101 |
| ACT during experiment (s) | 222 | 315 | 208 | 194 | N/A | 235 |
ACT Activated clotting time, SD standard deviation
*Blood flow depicted in ml/min but measured in weight per 30s