Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 14;25:25. doi: 10.1186/s13058-023-01630-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — MUC16 regulates HuR in TNBC cells. A. Volcano plot demonstrating decreased expression of ELAVL1/HuR, MMP1, and MMP3 in MUC16 knockdown TNBC cells. B. Gene ontology analysis of MUC16-associated pathways suggests its role in RNA biosynthesis, apoptotic and cell motility, and migration pathways. C. Bar diagram of qRT-PCR showing decreased HuR expression in MUC16 knockdown cells (MDA MB 231) compared to scramble. Actin was used as an internal control. D, E. Western blot results indicated that HuR was downregulated in MUC16 knockdown (MDA MB 231 and HCC1806). F. METABRIC dataset indicated co-expression of MUC16 and HuR in TNBC. G. Kaplan–Meier survival plot (Q15717) showing HuR is associated with poor survival in breast cancer patients (https://kmplot.com). H. HuR expression in different breast cancer subtypes (TCGA-METABRIC)