Table 2.

Characteristics of the included observational studies

Study	Study design	Data sources	Funding	Location	No of centres	No of participants	Median follow-up duration	Mean LDL-C (mg/dL) at baseline	Prevention type
Barkas et al31	Retrospective cohort study	NR	Not funded	Greece	Single centre	796	6.84 years*	177.8	Primary
Kim et al32	Retrospective cohort study	Electronic medical records	Ministry of Health and Welfare, Republic of Korea	Korea	Single centre	665	4 years	NR	NR
Kłosiewicz-Latoszek et al33	Retrospective cohort study	NR	Sanofi	Poland	Single centre	190	7.70 years†	239.8	Primary†
Rivers et al34	Retrospective cohort study	Electronic medical records	Sankyo Pharma	US	Single centre	16	Phase 1: 305 days; phase 2: 199 days	166	NR

LDL-C=low density lipoprotain cholesterol (1 mg/dL=0.0259 mmol/L); NR=not reported.

*Mean was estimated from median and interquartile range.

†Data in specific subpopulation of interest were not available, so data in overall population were presented.