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Tetravalent design of anti-PD1/CTLA-4 bispesific antibody cadonilimab based on co-expression of PD-1 and CTLA-4 in tumor tissue. (a) Correlation analysis of PD-1 and CTLA-4 mRNA expression levels in various tumor types from TCGA dataset using cBioportal. The X- and Y-axis represent the mRNA expression level transformed by Log(value+1). TCGA, The Cancer Genome Atlas. (b) Schematic diagram of cadonilimab tetravalent structure.
