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. 2023 Mar 5;15(1):2180794. doi: 10.1080/19420862.2023.2180794

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Cadonilimab induce IL-2 and IFN-γ production in mixed lymphocyte reaction assays. (a, b) Cadonilimab promoted activation of human peripheral blood mononuclear cells (hPBMCs), which induced a more robust secretion of IL-2 and IFN-γ in mixed culture of hPBMCs and human DCs; Compared with nivolumab plus ipilimumab, cadonilimab did not significantly improve secretion of IL-2 and IFN-γ. (c, d) Cadonilimab enhanced secretion of IL-2 and IFN-γ in mixed culture of hPBMCs and Raji-PDL1 cells. Data are shown as mean ±SEM for n = 2 and analyzed using one-way ANOVA. *P < .05, **P < .01 and ***P < .001 vs. isotype control.