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. 2022 Sep 15;19(4):1239–1257. doi: 10.1080/15548627.2022.2123098

Figure 6.

Figure 6.

Promotion of insulin secretion by autophagy requires RAB37 in mice. (A) After IPGTT, the concentrations of insulin and glucose in the blood of Rab37+/+ and rab37-/- male mice were evaluated by ELISA. (B) the coexistence of insulin (green) and LC3 (red) in the tissue sections of islets of Langerhans from Rab37+/+ and rab37-/- mice after feeding with chow diet (CD) together with niclosamide (1500 p.p.m.) for 14 days under a confocal microscope, N = 200. (C) Rab37+/+ and (D) rab37-/- mice were fed with CD in the presence or absence of niclosamide for 14 days followed by IPGTT. The concentrations of insulin and glucose in the blood of these mice were measured at the times as indicated. Data were presented as mean ± SEM. N = 4   9 mice per group. Student’s t-test was used for statistical analysis. ns: no significance. Scale bars: 10 μm.