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. 2023 Mar 9;24(1):2184145. doi: 10.1080/15384047.2023.2184145

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of VEGF overexpression on VEGF levels in MDA-MB-231 cells and tumors, vessel density as detected by CD31 immunostaining, and tumor volume doubling time. — Validation of VEGF Overexpression. (a) Validation of the overexpression of VEGF in the supernatant of 231_VEGF cells (N = 5) compared to 231_WT cells (N = 5). (b) Validation of the overexpression of VEGF in tumors derived from 231_VEGF cells (N = 5) compared to tumors from 231_WT cells (N = 5). (c) Representative CD31 immunostained images from 231_WT (left) and 231_VEGF (right) tumors. (d) Quantification of strongly positive pixel (NSP) area normalized to the total pixel area in 231_WT (N = 5) and 231_VEGF (N = 5) tumors. 1 section was analyzed from each tumor. (e) Growth curves of 231_WT and 231_VEGF tumors (N = 10 per group); each point in the graph represents a single tumor volume. Values represent Mean ± S.E.M. *P ≤ .05,****P ≤ .00005.