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. 2023 Mar 9;24(1):2184145. doi: 10.1080/15384047.2023.2184145

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Changes in MDA-MB-231 tumor collagen 1A1 and fibronectin-1, enzymes, and fibroblast markers with VEGF overexpression as detected by immunoblotting of tumor tissue. — Immunoblot analysis of ECM proteins and enzymes in tumors. (a) Decrease of Col1A1 and fibronectin identified in 231_VEGF compared with 231_WT tumor samples. (b) Increase of MMP-1 in 231_VEGF compared with 231_WT tumor samples. (c) Decrease of MMP-2, and increase of uPAR in 231_VEGF compared with 231_WT tumor samples. (d) Decrease of ADAMST1 and (e) increase of LOX in 231_VEGF compared with 231_WT tumor samples. (f) Increase of α-SMA and decrease of FAP-α in 231_VEGF compared with 231_WT tumor samples. GAPDH was used as a loading control. n = 5 for 231_WT and n = 5 for 231_VEGF in all immunoblots.