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. 2023 Mar 7;15(1):2185924. doi: 10.1080/19420862.2023.2185924

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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An arrowed flow chart describing various stages of biologics discovery and development, going from hit generation to hit screening, lead optimization, lead selection and CMC development. Specific activities for each stage are listed. — Diagram highlighting various discovery and early development stages for large-molecule therapeutic antibody developability. Later-stage CMC development key deliverables are also listed.