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. 2022 Jun 1;2:904480. doi: 10.3389/fnetp.2022.904480

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Copyright © 2022 Berner, Sawicki, Thiele, Löser and Schöll.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of the sepsis model. (A) A tissue element is depicted, in which the basic processes of sepsis take place: shown are the cells (colored) involved such as parenchymal, fibroblast, endothelial cells, and macrophages, polymorphonuclear leukocytes and thrombocytes in the parenchyma (grey), the stroma (yellow), and the capillary blood vessel. (B) depicts the functional interactions within and between the two corresponding network layers in our model, the parenchyma and the stroma (immune layer).