TABLE 1.

Physiological meaning of the dynamical variables, parameters and measures of the model (superscripts referring to layers μ = 1 and μ = 2 omitted).

	Symbol	Name	Physiological Meaning
Dynamical Variable	ϕ i	Phase	Metabolic activity
	κ ij	Coupling weight	Cytokine activity
Parameter	α	Phase lag	Metabolic interaction delay
	β	Plasticity rule	Age, inflammaging, pre-existing diseases, etc.
	ω	Natural frequency	Natural frequency of cellular metabolism
	ϵ	Time scale ratios	Time scales of cytokine activity
	C	Initial network perturbation	Local infection
	a ij	Connectivity	Fixed parenchymal cell-cell interaction
	σ	Interlayer coupling	Interaction between immune and parenchymal cells
Measure	$⟨\dot{{\varphi }_i}⟩$	Mean phase velocity	Collective frequency of cellular metabolism
	s	Standard deviation of	Pathogenicity (parenchymal layer)
		Frequency (see Eq. 5)	Activation (immune layer)
	f	Frequency cluster ratio	Probability of a pathological state