FIGURE 2.

Time traces of the modified Korenčič model in constant darkness (DD) (top), 12:12 light-dark cycles (LD) (middle, grey bars indicate the dark phase) and 12:12 drug—no drug cycles (bottom, drug presence visualised as square wave). Both zeitgebers result in successful entrainment to a period of 24 h. The simulation of a Rev-Erbα agonist (+REV) was chosen as drug. For the equations and parameter values of the simulations Supplementary Equation S1-1. All plots show Bmal1 _x , Rev−erb _x , Per _x , Cry _x , and DBP _x .