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. Author manuscript; available in PMC: 2023 Mar 14.
Published in final edited form as: Curr Med Chem. 2019;26(15):2634–2660. doi: 10.2174/0929867325666180508095242

Figure 8. Inhibition of PP2B by immunophilin/immunosuppressant complex.

Figure 8.

Inhibition of PP2B by immunophilin/immunosuppressant complex. A. The structure of a PP2B holoenzyme is shown in a cartoon representation. The PP2B catalytic subunit is green, the regulatory B subunit is cyan, and the autoinhibitory domain is white. Metal ions are shown as spheres: Fe is red, Zn is blue, and Ca is orange. B. The structure of a PP2B holoenzyme bound to the inhibitory FKBP12:tacrolimus complex is shown in a cartoon representation. The PP2B catalytic subunit is green, the regulatory B subunit is cyan, and FKBP12 is magenta. Metal ions are shown as spheres: Fe is red, Zn is blue, and Ca is orange. Tacrolimus (FK506) is shown as sticks