. 2023 Mar 14;6(1):ooad016. doi: 10.1093/jamiaopen/ooad016

Table 2.

Summary of significant features in the 2 comparison cohorts

Major systemic findings, or conditions (general and specific)
Diseases of the nervous system	Migraines, headache syndromes, sleep disorders, insomnia, chronic pain, dysautonomia, post-viral fatigue syndrome, encephalitis, encephalopathy^a, disorders of autonomic nervous system, sleep apnea, transverse myelitis^a
Mental and behavioral disorders	Anxiety disorders, severe stress and adjustment disorders, organic including symptomatic mental disorders, obsessive-compulsive disorder^a, dissociative and conversion disorders, mood disorders
Diseases of the respiratory system	Asthma, ARDS/respiratory failure, diseases of vocal cords and larynx, tonsilitis, exercise induced bronchospasm^a, pulmonary edema^a
Diseases of the circulatory system	Arrhythmias, cerebrovascular disease, thromboembolic disease, hypotension, tachycardia^a, cardiac murmurs^a
Disease of the musculoskeletal system and connective tissue	Pain in joints, pain in limbs, dorsalgia, myalgias, hypermobility syndrome, soft tissue disorders, muscle disorders, arthropathies, osteopathies, disorders of bone, reactive arthritis, physeal arrest, osteomyelitis^a
Diseases of the digestive system	Diseases of oesophagus, stomach, and duodenum, aphagia and dysphagia, diseases of liver^a
Diseases of blood	Anemias^a, sickle cell disorders^a
Endocrine, nutritional, and metabolic diseases	Nutritional deficiencies^a, obesity and overweight, disorders of mineral metabolism^a, volume depletion or fluid overload, obesity, hyperkalemia^a
Renal/Urinary	Acute kidney failure^a, signs and symptoms involving the urinary system, hematuria
Diseases of the eye	Disorders of refraction and accommodation^a
Immunologic findings	Other disorders involving the immune mechanism not elsewhere classified, cytomegaloviral disease^a
Major syndromic findings, or symptoms
Circulatory and respiratory signs and symptoms	Palpitations, cough, dyspnea, shortness of breath, chest pain, viral and bacterial pneumonia, snoring, asphyxia and hypoxemia, hyperglycemia^a
GI signs/symptoms	Abdominal pain, nausea/vomiting, diarrhea^a, constipation^a, gastroenteritis^a, pressure ulcer^a
CNS/musculoskeletal signs/symptoms	Lack of coordination, abnormalities of gait and mobility
Cognition, perception, emotional state	Dizziness, smell/taste disturbances, restlessness and agitation^a, disorientation^a, depressive episode
General signs and symptoms	Fatigue/malaise, muscle weakness, headache, weakness, syncope and collapse, pain not elsewhere classified, fever^a, enlarged lymph nodes^a, nasal congestion^a, epistaxis, noninflammatory disorders of female genital tract^a, other inflammation of vagina and vulva^a, visual disturbances
Skin	Symptoms and signs involving the skin and subcutaneous tissue, eczema,^a urticaria^a and erythema^a, paresthesia of skin^a

Findings significant in PASC vs COVID-negative comparison but not PASC vs COVID-positive comparison.