Fig. 4.

Cellular and molecular profile of invasion in GBM.

(A) Volcano plot showing differentially expressed genes between invasive and nodular GBM samples. Positive fold-change means gene is upregulated in invasive GBM. log₂FC > 0.5 was considered significant. Q-value < 0.05 was considered significant. (B) Differentially expressed regulons between invasive and nodular GBM samples. Positive fold-change means regulon is upregulated in invasive GBM. (C) Canonical pathways significantly upregulated in invasive GBM samples. (D) Cellular functions significantly upregulated in invasive GBM samples.