Fig. 6.

Overexpression of CRYAB increases tumor recurrence after surgical resection.

(A) Representative IVIS images 1 week, 2 weeks, and 3 weeks after inoculation of the indicated tumor cells without surgical intervention. (B) Quantification of (A) showing that GBM30-DsRed tumors are larger than GBM30-CRYAB tumors 3 weeks after tumor inoculation. n = 5. (C) Schematic of mouse GBM resection model. (D) Representative IVIS images before, after, and 10 days-after surgical resection of tumor in mice inoculated with GBM30-DsRed or GBM30-CRYAB cells. (E) Quantification of (D) showing that GBM30-CRYAB tumors have greater recurrence than that of GBM30-DsRed tumors 10 days post-surgery. n = 4. (F) Survival of mice inoculated with GBM30-DsRed or GBM-CRYAB cells after surgical resection of the tumor. n = 5.