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. 2022 Nov 19;8(2):e10408. doi: 10.1002/btm2.10408

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© 2022 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Small angle x‐ray scattering (SAXS) characterizations of DOX‐HA‐CPT in PBS. (a) The SAXS data were fitted to the model of Worm‐Like Chain to characterize the equilibrium rigidity of polymers (described by Kuhn segment length), and the interparticle interactions (described by radius of hard sphere repulsion, RHS). (b) Strong scattering intensities of the drug conjugates and their model fittings show the morphological transition on the polymeric chain in R5 and R15. I refers to the scattering intensity and q represents the scattering vector. (c) A clear relationship is identified between RHS and Kuhn segment length as a function of drug ratio, R.