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. 2023 Feb 21;8(2):e10443. doi: 10.1002/btm2.10443

FIGURE 2.

FIGURE 2

Administration of hWJCM decreases the PASI index in an IL‐17A reporter mice model with PD. (a) PASI scores for skin thickness, (b) PASI scores for scales, (c) PASI scores for erythema, (d) overall PASI scores. Ctrl (black), PD (red) Clob (purple), hWJCM (green). (e) Total PASI score at day 13. (f) Skin thickness (mm). Analysis per 10,000 permutations, α = 0.05, n = 4. (g) Representative image of histological section of healthy skin (h) Representative image of histological section of skin after 12‐days of PD induction. Typical characteristics of the psoriatic phenotype were noted, such as hyperkeratosis (pink arrow), elongation of epidermal ridges (white arrow) and cellular infiltrate (highlighted in pink box). (h) Representative image of histological section of skin injected with hWJCM once a day for 9 consecutive days in the 12‐day PD induction protocol. Bar = 1 mm (T test, α = 0.05, n = 15)