FIGURE 4.

Cutaneous administration of HA hWJCM for 9 consecutive days improves dorsal skin appearance and decreases the thickness of the epidermis in a PD model. (a) Experimental procedure used for the induction of PD. Note that treatments were applied starting on Day 4 in a daily fashion up to Day 12. Clob, HA Ctrl, and HA hWJCM were applied topically while hWJCM was injected subcutaneously. Created with BioRender.com (b) Representative pictures of control mice and mice receiving experimental treatments, Clob, HA Ctrl, HA hWJCM, and hWJCM. (c) Hematoxylin/eosin staining of mouse skin sections at Day 13, Bar = 1 mm. (d) Quantification of epidermal thickness. One‐way ANOVA, α = 0.05, n = 15