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IL‐12 toxicity in healthy mice. (a), Schematic of dosing scheme in healthy animals. Mice were dosed with 5 μg IL‐12 in PLE‐IL‐12‐NPs, UL‐NPs, or carrier free and compared to 5% dextrose control. (b), Toxicity of various IL‐12 delivery methods administered IV (left) or IP (right) as measured by weight loss during and after dosing.**indicate p < 0.01 ***indicate p < .01 as measured by two‐way ANOVA with bonferroni post hoc test across all group N = 5
