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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Mol Psychiatry. 2022 Jun 29;27(10):4144–4156. doi: 10.1038/s41380-022-01673-w

Figure 4. Changes in metabolic activity induced by (2R,6R)-HNK differ from those produced by (S)-ketamine.

Figure 4.

Brain metabolic mapping using [18F]-FDG PET scanning in rats. [18F]-FDG uptake images obtained after administration of saline (baseline, n = 4) or (2R,6R)-HNK (10 mg/kg over 40 min, n = 5). They show the average SUVRWB (standardized uptake value ratio) calculated using the whole brain as a reference region (A,B). Voxel-based parametric mapping analyses revealed significantly increased metabolic activity from baseline values in areas such as the insula, nucleus accumbens, globus pallidus, dorsomedial thalamus, motor, sensory, and visual cortices, and midline cerebellum. Statistical parametric maps of significant decreases of [18F]-FDG uptake (P < 0.05, paired t test) (C). Regional [18F]-FDG uptake (SUVRWB) in the brain regions of animals infused with saline or (2R,6R)-HNK (D). Correlation matrices of the metabolic activity across brain regions of animals infused with saline, (2R,6R)-HNK or (S)-ketamine. The data corresponding to the (S) ketamine dataset was reported in [9]. Full data sets are available in Supplemental Information 6 (E).