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. 2023 Mar 2;19(3):e1011146. doi: 10.1371/journal.ppat.1011146

Fig 3. Drug response assays for ben-1 Q134H(CAA>CAC) alleles introduced into C. elegans by CRISPR-Cas9 editing.

Fig 3

Regressed median optical density (median.EXT), a proxy measurement of animal length, from populations of nematodes after exposure to 30 μM albendazole is shown. ben-1(ean64) is a previously created deletion strain. ben-1(ean243) and ben-1(ean244) are two independent CRISPR-Cas9 edited Q134H(CAA>CAC) alleles. Each point represents the regressed phenotype of a well containing approximately 50 animals. Data are shown as Tukey box plots with the median as a solid horizontal line, and the top and bottom of the box representing the 75th and 25th quartiles, respectively. The top whisker is extended to the maximum point within the 1.5 interquartile range from the 75th quartile. The bottom whisker is extended to the minimum point within the 1.5 interquartile range from the 25th quartile. Statistical significance is shown as asterisk above each strain (p < 0.001 = ***, p < 0.0001 = ****, Tukey HSD).