TABLE 4.
Clinical symptom correlations with PCC connectivity during neurofeedback training runs
| MNI coordinate | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Measure | Direction | PCC seed | Brain region | H | k | x | y | z | t‐Stat. | z‐Score | p‐FWE peak |
| Reg > View (Whole‐brain) | |||||||||||
| CTQ | + | Left | Ventral striatum/nucleus accumbens | R | 46 | 6 | 8 | −6 | 7.35 | 5.40 | .006 |
| DERS | + | Right | Amygdala | R | 71 | 16 | −6 | −12 | 6.59 | 5.04 | .039 |
| Reg > View (ROIs) | + | ||||||||||
| BDI | + | Left | Amygdala | R | 14 | 16 | −6 | −14 | 4.77 | 4.02 | .032 |
| + | Right | Amygdala | R | 22 | 16 | −6 | −12 | 5.28 | 4.34 | .009 | |
| CAPS‐5 total | + | Right | Amygdala | R | 34 | 20 | 0 | −16 | 5.25 | 4.32 | .009 |
| + | Right | Anterior insula | L | 28 | −32 | 22 | 6 | 4.79 | 4.04 | .032 | |
| CTQ | + | Left | dmPFC | 37 | 4 | 40 | 38 | 4.65 | 3.95 | .042 | |
| DERS | + | Left | Amygdala | R | 28 | 16 | −6 | −14 | 5.05 | 4.20 | .016 |
| + | Right | Amygdala | R | 47 | 16 | −6 | −12 | 6.59 | 5.04 | <.001 | |
| MDI | + | Right | Amygdala | R | 24 | 16 | −6 | −12 | 5.86 | 4.66 | .002 |
Note: Clinical correlations from the linear regression analyses between clinical scores and PCC functional connectivity during the neurofeedback training runs. The linear regression analyses were conducted across all study participants. Reported results for whole‐brain and ROI analyses are at a significance threshold of p‐FWE peak‐level < .05, k = 10. The measure column lists the specific clinical inventory or questionnaire administered. The direction of correlation (±), PCC seed, brain region, hemisphere of the region (H), cluster size (k), MNI coordinates (x, y, z), t‐statistic (t‐stat.), z‐Score, and significance (p‐FWE peak) for each significant peak result are included as columns. PPI = psychophysiological interaction, PCC = posterior cingulate cortex, H = hemisphere, FWE = family‐wise error, L = left, R = right, dmPFC = dorsomedial prefrontal cortex, CTQ = Childhood Trauma Questionnaire, DERS = Difficulties in Emotion Regulation Scale, BDI—Beck's Depression Inventory, CAPS = Clinician‐Administered PTSD Scale, MDI = Multiscale Dissociation Inventory.