Fig. 7.

Synergistic PTT/CDT antitumor effect of LET-11-Fe in vivo. (A) Thermal images of 4T1-tumor-bearing mice under 808-nm laser irradiation for 10 min (L1 indicates 0.8 W cm⁻² and L2 indicates 0.4 W cm⁻²). (B) Mean temperatures of tumors as a function of irradiation time. (C) Tumor growth curves, (D) representative photographs of dissected tumors, and (E) tumor weights after various treatments (n = 5). (F) Tumor growth curves of 4T1-tumor-bearing mice after different treatments. (G) H&E, (H) Ki67, and (I) TUNEL staining of tumor tissues. Scale bars, 50 μm. The data are presented as means ± SD, ****P < 0.0001, analyzed by 2-sided Student’s t test.