Table 2.
Association of Alzheimer's disease and neurodegeneration plasma biomarkers with lobar axonal density (NDI).
| Biomarker | Frontal Lobe NDI (N = 43) | Temporal Lobe NDI (N = 43) | Parietal Lobe NDI (N = 43) | Occipital Lobe NDI (N = 43) | ||||
|---|---|---|---|---|---|---|---|---|
| β Estimate (SE) | P | β Estimate (SE) | P | β Estimate (SE) | P | β Estimate (SE) | P | |
| Aβ42/40 | 0.23 (0.14) | 0.113 | 0.29 (0.14) | 0.043 | 0.23 (0.14) | 0.121 | 0.35 (0.13) | 0.014 |
| pTau181 | −0.21 (0.15) | 0.175 | −0.28 (0.15) | 0.072 | −0.22 (0.16) | 0.174 | −0.32 (0.15) | 0.044 |
| NfL | −0.23 (0.08) | 0.007* | −0.22 (0.08) | 0.012* | −0.25 (0.08) | 0.004* | −0.19 (0.08) | 0.026 |
| GFAP | −0.31 (0.08) | <0.001* | −0.27 (0.09) | 0.004* | −0.30 (0.09) | 0.001* | −017 (0.09) | 0.076 |
We used a linear regression model adjusted for age, sex and race for all analyses. β estimates represent the SD difference in plasma biomarker per each SD increase in lobar axonal density (NDI).
Abbreviations: Aβ42/40, ratio of amyloid‐beta 42 to amyloid‐beta 40; GFAP, glial fibrillary acidic protein; NfL, neurofilament light chain; pTau181, tau phosphorylated at threonine‐181; SE, standard error.
*
Indicates associations are statistically significant after Bonferroni correction for multiple comparisons (P < 0.013).