. 2023 Jan 8;22(3):e13776. doi: 10.1111/acel.13776

TABLE 1.

Differentially expressed proteins in ScAT and VsAT secretomes, SASP atlas, SenMayo gene set and media from irradiated human preadipocytes

Gene Id	p Value	Ratio	SASP Atlas				SenMayo	Irradiated preadipocytes
			Irradiated fibroblasts	Protease inhibitor fibroblasts	Inducible RAS Fibroblast	Irradiated epithelial cells
ACE	0.001953	0.65
ADAMTS1	0.000427	57.57
ADAMTS5	0.03125	0.82
AEBP1	0.044769	0.88
AGRN	0.03125	29.43	+	+	+
ALB	0.003845	1.96	+		+
ANXA2	0.001678	0.81		+	+	+
APCS	0.012207	1.75
APLP2	0.005569	2.25
APOA1	0.00293	55.76			+
APOC3	0.009766	1.60			+
APOD	0.000153	0.52
ARPC1A	0.03418	22.82
B4GALT1	0.028992	1.39		+
BGN	0.003159	1.76		+	+
C1QBP	0.000381	25.15
C4A	0.007813	2.19
C4B	0.003906	4.58
C7	0.000031	65.24
CAB39L	0.000488	0.44
CALR	0.000015	1.96	+	+	+
CCDC80	0.00029	2.35
CD59	0.006653	1.28			+
CFD	0.000107	0.44
CFH	0.000031	0.39		+
CFI	0.000488	230.90			+
CHI3L1	0.000122	294.27
CHID1	0.002441	20.90
CILP	0.002441	0.60
CLEC3B	0.000031	0.25		+	+
CMA1	0.04187	37.97
COL12A1	0.000031	0.50	+	+	+
COL14A1	0.003906	0.60
COL18A1	0.010742	23.76		+
COL1A1	0.000381	0.65		+
COL1A2	0.003845	0.71		+
COL3A1	0.000107	0.48		+
COL5A2	0.028992	0.91			+
COL6A1	0.00029	0.61	+	+	+
COL6A2	0.000153	0.59	+	+	+
COL6A3	0.000153	0.45	+	+	+
CPA3	0.010986	0.80
CREG1	0.00029	1.92
CTHRC1	0.006836	0.67	+		+
CXCL1	0.003845	6.44	+	+	+		+	+
CXCL2	0.027344	1.83	+	+	+		+
CXCL3	0.008545	3.07	+	+	+
CXCL6	0.000092	735.04					+
CXCL8	0.000854	3.11	+		+		+	+
CYR61	0.038635	233.45		+	+
DCN	0.001343	0.60		+		+
ECM1	0.000031	0.44	+	+	+
EMILIN2	0.000076	2.12
ENPP2	0.000488	0.39		+
F2	0.000061	195.33			+
F5	0.000214	32.05		+
FAM114A1	0.03125	0.85
FBLN1	0.000381	0.50		+	+
FBLN2	0.000381	0.59		+
FBN1	0.000504	0.59		+	+
FGF7	0.001953	2.01					+
FGG	0.03125	1.44
FN1	0.020157	0.79	+	+	+
FST	0.000092	0.41
FSTL1	0.001343	0.67		+
GALNT2	0.037109	48.98	+
GC	0.003906	53.89	+		+
GGH	0.020996	0.87
GNAS	0.005157	1.29
GREM1	0.000977	324.39
GSN	0.000015	0.37	+	+	+	+
HMCN1	0.013672	0.75
HP	0.010986	1.83
HPX	0.001678	48.49
IGF2	0.000061	2.42		+	+
IGFBP3	0.000015	24.82	+	+		+	+
IGFBP4	0.000504	2.79	+	+	+		+
IGFBP7	0.000031	2.54	+	+			+
IGHG1	0.000214	85.05
IGHG3	0.023438	22.28
IGHG4	0.015625	54.44
IGKC	0.006653	1.96
IL6	0.000732	93.41					+	+
INHBA	0.000031	338.34					+	+
ISLR	0.023438	0.83
ITGBL1	0.000977	0.37
ITIH4	0.020996	19.22
ITLN1	0.000244	1087.89
KRT85	0.027344	510.83
LAMB1	0.000656	1.65	+	+	+
LAMB2	0.000381	0.63		+	+	+
LBP	0.03125	330.45
LGALS1	0.000656	0.74	+	+	+
LGALS3	0.000015	0.54	+	+		+
LGALS3BP	0.039536	1.47	+	+	+
LIF	0.000122	402.14
LOX	0.003357	58.52		+
LOXL2	0.023438	0.84	+	+	+
LTBP2	0.001007	1.78			+
LTBP4	0.047913	28.77			+
MASP1	0.007813	0.58		+
METRNL	0.024414	0.87
MFAP5	0.015625	0.69
MIF	0.000046	1.69	+	+	+		+
MMP10	0.001678	0.56					+
MMP14	0.029541	1.98			+		+
MMP3	0.000015	0.18			+		+	+
MMP9	0.003159	45.56			+		+
MSLN	0.03125	249.28
MYDGF	0.003357	1.48	+		+
NAMPT	0.014999	0.81	+		+
NID2	0.005859	1.69	+		+
NRP2	0.001953	147.98
OGN	0.000122	2.59
PAM	0.044312	0.90
PAMR1	0.01825	1.75
PAPPA	0.000031	2.51					+
PCOLCE	0.007904	0.74		+	+
PCOLCE2	0.000153	0.57
PDGFRL	0.002441	0.69
PI3	0.044769	0.97
PLAT	0.000031	972.35			+		+
PLAU	0.000031	176.63	+		+		+
PLG	0.013672	51.15		+
PLXDC2	0.027344	41.60
POSTN	0.000015	0.24	+	+	+
PRG4	0.00209	0.64
PSAP	0.026672	1.32	+	+	+
PTGDS	0.001068	268.45
PXDN	0.047913	1.30	+	+	+
QSOX1	0.001678	1.39	+	+	+
RNASE4	0.024414	0.79		+	+
S100A13	0.000031	0.52
SDC4	0.001678	1.74
SEPT8	0.039795	1.27
SERPINB2	0.000107	2.75			+
SERPINC1	0.001068	125.93
SERPINE1	0.000015	3.30	+	+	+		+
SERPINE2	0.000504	2.39		+			+
SERPINF1	0.000031	0.43		+	+
SERPING1	0.030518	0.82		+
SFRP2	0.038635	2.02
SFRP4	0.047913	83.82
SLIT2	0.007813	0.72
SLPI	0.010254	70.58
SOD3	0.000015	0.25		+
SPON1	0.01825	2.53				+
STC2	0.006714	1.84				+
TF	0.002136	34.82
TGFBI	0.03479	28.33	+	+
TGFBR3	0.026672	1.78
THBS1	0.000153	2.35	+	+	+
THBS2	0.000839	1.93		+	+
TNXB	0.000076	0.48
TPSAB1/TPSB2	0.000061	0.25
TXN	0.001068	0.75			+
TYMP	0.000015	0.26
VCAN	0.000046	0.55	+	+	+
VTN	0.000763	1.82
WISP2	0.000061	0.25
YBX1	0.030151	0.88	+		+

Note: Proteins were selected from available datasets (SASP atlas) as statistically upregulated by senescence stimuli in conditioned media.